Histo-Clear
HISTOLOGY AND TISSUE PROCESSING
Histo-Clear
Histological Clearing Solvent for Tissue Processing and Microscopy

Product Information
CAT#: 0905-NAT1332
Product Name: Histo-Clear
Brand: NATIONAL DIAGNOSTICS
Size: 5 US Gallon - 18.9 L
BUOM: EACH
Dry Ice: No
Hazardous: Yes
Availability:
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product Description
Histo-Clear is a histological clearing solvent used in tissue processing and microscopy workflows. Clearing is an essential step in preparing biological specimens for paraffin embedding and microscopic examination.
During conventional histological processing, tissue samples are dehydrated through a series of alcohol solutions before the clearing stage. A clearing solvent helps replace the dehydrating agent within the tissue and prepares the specimen for infiltration with a suitable embedding medium.
Histo-Clear is designed for laboratory histology procedures involving tissue preparation, paraffin processing and slide preparation. Proper clearing supports the transition between dehydration and paraffin infiltration, contributing to the preparation of specimens for subsequent sectioning and staining.
It is intended for professional laboratory use in histology, pathology, tissue research and microscopy applications. Always follow the manufacturer's instructions and the applicable laboratory safety procedures.
Key Features
- Histological clearing solvent for laboratory tissue processing.
- Used in workflows between tissue dehydration and paraffin infiltration.
- Suitable for histology and microscopy sample preparation.
- Supports conventional tissue processing procedures.
- Available in a large-volume 18.9 L container.
- Suitable for professional laboratory applications.
Applications
- Histology: Clearing of dehydrated tissue specimens during histological preparation.
- Paraffin Processing: Preparation of tissue samples for paraffin infiltration.
- Pathology Laboratories: Tissue preparation for microscopic examination.
- Microscopy: Preparation of biological specimens for histological slide workflows.
- Research Laboratories: Tissue preparation for morphological and structural studies.
How Does Tissue Clearing Work?
Tissue clearing is a key stage in conventional paraffin histology. It allows a clearing solvent to replace the alcohol used during dehydration, preparing the tissue for paraffin infiltration.
Step 1 – Fixation
Preserve tissue structure using an appropriate fixative.
Step 2 – Dehydration
Remove water from the tissue through graded alcohol solutions.
Step 3 – Clearing
Replace the dehydrating agent with a suitable clearing solvent.
Step 4 – Paraffin Infiltration
Allow molten paraffin to penetrate the cleared tissue.
Step 5 – Embedding and Sectioning
Prepare tissue blocks and cut thin sections for microscopic analysis.
Appropriate processing times depend on tissue type, specimen dimensions, processing equipment and the validated laboratory protocol.
Technical Specifications
Product Name: Histo-Clear
Catalog Number: 0905-NAT1332
Brand: NATIONAL DIAGNOSTICS
Product Category: Histology and Tissue Processing
Product Type: Histological Clearing Solvent
Size: 5 US Gallon - 18.9 L
BUOM: EACH
Dry Ice: No
Hazardous: Yes
Safety and Handling
Histo-Clear is classified as a hazardous product in the supplied product information. Appropriate laboratory precautions must be followed during storage, handling and use.
- Consult the current Safety Data Sheet (SDS) before use.
- Wear suitable laboratory gloves, protective clothing and eye protection.
- Use appropriate laboratory ventilation and follow the SDS recommendations.
- Avoid inhalation, ingestion and direct skin or eye contact.
- Keep the container properly closed when not in use.
- Follow applicable hazardous chemical disposal regulations.
Safety Notice: Refer to the manufacturer's SDS for the exact chemical hazards, storage requirements and emergency procedures.
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